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Buy 2-MPPP Online 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one is a compound structurally derive from 2-Aminopropan-1-one in which the Nitrogen is connect to the Carbon in the 3-position. So, The physiological and toxicological properties of this compound have not been studied. Because,
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Also, 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one may be utilised by researchers who wish to use it as a reference sample for their Gas chromatography/mass spectrometry (GC/MS), Fourier transform infrared spectroscopy(FTIR) or Nuclear magnetic resonance(NMR) analysis catalogues. Also,
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The intermediate tertiary alcohol is liable to dehydration in acidic conditions if the reaction temperature rises above 30 °C. Kidston did not realize this and esterified the intermediate with propionic anhydride at an elevated temperature. Consequently, MPTP was forme as a major impurity.1-Methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, causes rapid onset of irreversible symptoms similar to Parkinson’s disease.
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MPTP is metabolize to the neurotoxin MPP+ by the enzyme MAO-B, which is expresse in glial cells. This selectively kills brain tissue in the area of the brain called the substantia nigra and causes permanent Parkinsonian symptoms.Structural analogs of desmethylprodine with different N-substituents than a methyl group on the piperidine have been investigated. Several of these have significantly greater in vitro potency compared to desmethylprodine.